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Antipain dihydrochloride

CAS No. 37682-72-7

Antipain dihydrochloride( —— )

Catalog No. M34163 CAS No. 37682-72-7

Antipain dihydrochloride (Antipain 2HCl) is a protease inhibitor derived from Actinomycetes that exhibits analgesic activity and inhibits X-ray-induced chromosomal aberrations in human lymphocytes.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Antipain dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Antipain dihydrochloride (Antipain 2HCl) is a protease inhibitor derived from Actinomycetes that exhibits analgesic activity and inhibits X-ray-induced chromosomal aberrations in human lymphocytes.
  • Description
    Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice.
  • In Vitro
    ——
  • In Vivo
    The intact, cycling female mice received subcutaneous injections of Antipain dihydrochloride (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls.Antipain dihydrochloride (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice.
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Serine Protease
  • Recptor
    Protease
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    37682-72-7
  • Formula Weight
    677.62
  • Molecular Formula
    C27H46Cl2N10O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=CC(CCCNC(N)=N)NC(C(C(C)C)NC(C(CCCNC(N)=N)NC(NC(CC1=CC=CC=C1)C(O)=O)=O)=O)=O.Cl.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. DiPaolo JA, et al. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6649-53.?
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